A system that facilitates access to an SMBus is provided. The system includes a notification component that identifies an SMBus event and a driver that dispatches the SMBus event to an AML event handler. A method for SMBus event handling is also provided. The method includes receiving an SMBus event notification, identifying the SMBus event notification, dispatching the SMBus event notification to an AML event handler, and handling the SMBus event notification in AML code. Two new ACPI opcodes, which are a three parameter operation region read and a three parameter operation region write can be utilized in accordance with the present invention.