This invention provides a hand held pipette which is ergonomically designed to reduce user fatigue and injury. The pipette preferably includes a nozzle extending downward at a selected angle from a point near the top of a base portion of the pipette, the base portion being grasped by the operator's hand, and may also include a hook extending from a second point near the top of the body portion which is angularly spaced from the first point, which hook extends over a portion of a user's hand to support the pipette thereon. The pipette is also designed to permits operation with the user's wrist and arm in a neutral position and minimizes local pressure points on the operator's hand.