A negative pressure, compression therapy device is described in this application. It has (a) a heel care boot having a fluid, (b) a pressure bag having an opening that receives the patient's foot and the heel care boot, and (c) a vacuum system that generates a modulatable negative pressure in the pressure bag. The negative pressure in the pressure bag is sufficient to cause the patient's veins to vasodilate and the negative pressure modulates to cause the fluid in the heel care boot to provide compression therapy to the patient.