The present invention relates to a method and also an imaging system to compensate for patient motion when recording a series of images in medical imaging, in which a number of images of an area under examination of a patient (17) are recorded at intervals with an imaging system (1) and are related to one another. With the method a localization system (2) is used as the series of images are being recorded to permanently or at a time close to the recording of the individual images, record a momentary spatial location of the area under examination in a reference system permanently linked to the imaging system (1), a first spatial location of the area under examination recorded close to the time of recording of a first image is stored, and a deviation of the images recorded momentarily in each case of the first spatial location is determined and by changing the geometrical circumstances of the imaging system (1) at a time to close the recording of the spatial location and/or through geometrical adaptation of an image content of an image just recorded, is at least approximately commentated for, so that the images show the area under examination in the same position and orientation. The method does not require any time-consuming interaction with the operator and is also suitable for compensating for larger movements of the patient.