The present invention provides compounds of formula I that are useful as
potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase
1. The present invention further provides a pharmaceutical composition
which comprises a compound of Formula I, or a pharmaceutical salt
thereof, and a pharmaceutically acceptable carrier, diluent, or
excipient. In addition, the present invention compositions containing
these compounds for the treatment of metabolic syndrome, diabetes,
hyperglycemia obesity, hypertension, hyperlipidemia, other symptoms
associated with hyperglycemia, and related disorders. Formula I wherein
G.sup.1 is methylene or ethylene; L is --(C.sub.1-C.sub.4)alkylene-,
--S--, --CH(OH)--, or --O--; R.sup.0 is Formula II or Formula III and the
other substituents are as defined in the claims.