Systems and methods for maintaining data stream synchronization are provided. A system comprises one or more radio head interface modules and a call processing software module each adapted to communicate with each other. The call processing software module performs modulation and demodulation of voice and data streams using one or more air interface standards. The call processing software module communicates a forward data stream to a first radio head interface module. The forward data stream comprises a plurality of data samples representing voice and data streams and a plurality of fixed synchronization words. When the first radio head interface module does not observe the receipt of a first fixed synchronization word of the plurality of fixed synchronization words word from the call processing software module when expected, the first radio head interface module concludes that it has lost synchronization with the call processing software module.