A method of automatically assessing skeletal age of hand radiographs, comprising: providing a radiographic image of both two hands; cropping a first image of the left hand or the right hand; rotating the first image to make the fingertip of the medius point upwards the vertical; cropping a second image of the medius; segmenting the phalanges of the medius to acquire a third image; extracting a plurality of physiological features of the third image to acquire a first data; extracting a plurality of morphological features of the third image to obtain a second data; delivering the first data and the second data to a neural network for training; and outputting an assessment of the skeletal age.