Methods for treating and/or preventing cardiovascular diseases and diseases related thereto by administering a therapeutically effective amount of one or more first compound(s) having a beta3-adrenoceptor agonistic effect and a therapeutically effective amount of one or more second compound(s) having a beta1/beta2-adrenoceptor antagonistic effect are disclosed. The first compound(s) and the second compound(s) are used simultaneously, separately or sequentially as a combined preparation. Related cardiovascular diseases include arterial diseases, ischemic and failing cardiac diseases, including heart failure, conditions related to metabolic syndrome or angiogenesis-related disease. Pharmaceutical compositions are also described.