An air-clad optical fiber is provided having a core that is surrounded by an inner cladding region, an air-clad region, and an outer region. A lead end of the air-clad optical fiber is prepared for splicing by removing the air-clad region and all fiber regions outside of the air-clad region, so as to expose an inner fiber region. The prepared lead end of the air-clad optical fiber is then spliced to a lead end of the optical device. The air-clad region may be removed from a selected portion of an air-clad fiber by causing an etchant gas to stream through the air-clad region in the selected portion of the fiber. Heat is then applied to the selected fiber portion, causing at least some of the microstructure to be etched away.