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A pharmaceutical composition having thrombolytic, anti-inflammatory and
cytoprotective properties is described. The composition contains active
proteases attached to a gel or to a mixture of a gel with a water-soluble
polymer, said attachment being achieved with the help of radiation,
preferably with the help of gamma-radiation or a flow of accelerated
electrons. As the proteases the composition contains proteases which are
stable at a temperature of up to 70.degree. C., preferably at
30-40.degree. C., for instance such as subtilysine, trypsin,
chemotrypsin, papain or streptokinase. The gel is preferably polyethylene
glycol gel, dextran gel, or polyglycane gel, and the water-soluble
polymer is polyethylene glycol, polyvinyl alcohol, dextran or
polyglycane. The method of preparing said composition and its use are
also disclosed. The composition has a broad range of application, and can
be used in cardiology, nephrology, surgery, rheumatology, gynecology and
gastroenterology.
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< 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor
> Compositions and methods of use of targeting peptides against placenta and adipose tissues
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~ 00464
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