A therapeutic agent for hyperlipidemia which has no side effects on the liver unlike conventional MTP inhibitors and has excellent MTP inhibitory activity. Also, provided is an ester compound represented by the general formula (1): ##STR00001## or a pharmaceutically acceptable salt thereof.

 
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> Substituted 1,4,-di-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists
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