This invention relates to N-aroyl cyclic amine derivatives and their use
as orexin antagonists ##STR00001## wherein: Y represents a bond, oxygen,
or a group (CH.sub.2).sub.n, wherein n represents 1, 2 or 3; m represents
1, 2, or 3; p represents ) or 1; X is NR, wherein R is H or
(C.sub.1-4)alkyl; Ar.sup.1 is aryl, or a mono or bicyclic heteroaryl
group containing up to 3 heteroatoms selected from N, O and S; any of
which may be optionally substituted; A.sup.2 represents phenyl or a 5- or
6-membered heterocyclyl group containing up to 3 heteroatoms selected
from N, O and S, wherein the phenyl or heterocyclyl group is substituted
by R.sup.1 and further optional substituents; or Ar.sup.2 represents an
optionally substituted bicyclic aromatic or bicyclic heteroaromatic group
containing up to 3 heteroatoms selected from N, O and S; R.sup.1
represents hydrogen, optionally substituted (C.sub.1-4)alkoxy, halo,
cyano, optionally substituted (C.sub.1-6)alkyl, optionally substituted
phenyl, or an optionally substituted 5- or 6-membered heterocyclyl group
containing up to 4 heteroatoms selected from N, O and S; when Ar.sup.1 is
aryl p is not 1, or a pharmaceutical acceptable salt thereof.