According to the invention, there is provided a novel soybean variety designated XB22N06. This invention thus relates to the seeds of soybean variety XB22N06, to the plants of soybean XB22N06 to plant parts of soybean variety XB22N06 and to methods for producing a soybean plant produced by crossing plants of the soybean variety XB22N06 with another soybean plant, using XB22N06 as either the male or the female parent.