The invention relates to a multiparticulate drug form suitable for uniform
release of an active pharmaceutical ingredient in the small intestine and
in the large intestine, comprising at least two forms of pellets A and B
which comprise an active pharmaceutical ingredient in the core and have
different polymer coatings which determine the release of the active
ingredient at different pH values, characterized in that pellet form A is
provided with an inner polymer coating which enables continuous release
of active ingredient, and has an outer enteric coating which rapidly
dissolves above about pH 5.5, and pellet form B is provided with a
polymer coating which, in the USP release test, releases less than 20% of
the active ingredient at pH 6.8 in 6 hours and releases more than 50% of
the active ingredient at pH 7.2 in 6 hours. The invention additionally
relates to a process for producing the multiparticulate drug form and to
the use of pellet forms A and B for producing the drug form.