The present invention relates to intermediates of the formula ##STR00001## useful in the preparation of piperazinyl-substituted indan derivatives, wherein Y is CONR.sub.2 wherein R.sub.2 is H or C.sub.1-C.sub.6 alkyl; R.sub.3 is C.sub.1-C.sub.6 alkyl, C.sub.3-C.sub.6 cycloalkyl or (CH.sub.2).sub.n-aryl, wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted with R.sub.4 and/or R.sub.5, wherein R.sub.4 and R.sub.5 are as defined in the specification; and R.sub.9 is H, C.sub.1-C.sub.6 alkyl, C.sub.3-C.sub.6 cycloalkyl, OCF.sub.3, OCHF.sub.2, OCH.sub.2F, halogen, CN, CF.sub.3, OH, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 alkoxy-C.sub.1-C.sub.6 alkyl, NR.sub.6R.sub.7, SO.sub.3CH.sub.3, SO.sub.3CF.sub.3, SO.sub.2NR.sub.6R.sub.7, an unsubstituted or substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituent(s) is(are) C.sub.1-C.sub.6 alkyl; or COR.sub.8; wherein R.sub.6, R.sub.7 and R.sub.8 are as defined in the specification. The invention further relates to a process for the preparation of the intermediates.

 
Web www.patentalert.com

< Fused heterocyclic kinase inhibitors

> Process for the synthesis of derivatives of halo-[2,3-F] quinoline

~ 00470