A heat exchanger and mount isolation system (10) is provided and includes a heat exchanger (12) for a vehicular application, a pair of side frame members (14,16) for mounting the heat exchanger (12) to a vehicle, and four pairs (18) of isolation mount assemblies (19) for mounting the heat exchanger (12) to the side frame members (14,16). The mount assemblies (19) are received in mounting bores (30) that are integral parts of the heat exchanger (12). Each of the pair 18 of mount assemblies (19) is inserted into the opposite ends (32,34) of a corresponding one of the mount bores (30) and includes a pair of abutting metal sleeves (42) that are mounted in respective annular flanged isolators (40).