A compound represented by the structural formula ##STR00001## and pharmaceutically acceptable salts and solvents thereof is disclosed, wherein: the single-dashed line ##STR00002## between the ring carbons to which R.sup.10 and R.sup.34 are attached represents either a single bond or a double bond; the double-dashed line ##STR00003## between X and the carbon to which Y is attached represents either a single bond or an absent bond; X is --O-- or --NR.sup.6-- when the double-dashed line represents a single bond; X is H, --OH or --NHR.sup.20 when the double-dashed line represents an absent bond; and other parameters are as defined herein. Also disclosed are pharmaceutical compositions and combinations containing said compounds and their uses as thrombin receptor antagonists and binders to cannabinoid receptors.