A process for removing viruses in fibrinogen solutions and fibrinogen
obtained thereof wherein the process starts with an adjusted purified
fibrinogen solution, the adjusted purified solution is frozen and then
thawed at a temperature between 5 and 20.degree. C., the undissolved
materials associated with the fibrinogen are subsequently separated, the
temperature is adjusted and the resultant solution is finally subjected
to nanofiltration using filters having a pore size smaller than 35 nm.