The present invention pertains to a sized product, which contains a drug,
polyethylene oxide with a molecular weight of 2,000,000 or higher, and a
specific size controlling agent for polyethylene oxide (substance with
the appropriate plasticity and binding force) and wherein at least the
above-mentioned specific size controlling agent is uniformly dispersed in
the above-mentioned polyethylene oxide, a controlled-release
pharmaceutical composition containing this sized product, and a method of
manufacturing a controlled-release pharmaceutical composition containing
this sized product.A controlled-release pharmaceutical composition with
good uniformity of content can be presented by using powder particles of
polyethtylene oxide with powder properties suitable for tableting, which
is obtained by uniform dispersion of the specific size controlling agent
for polyethylene oxide of the present invention.