Apparatus and methods for autonomously identifying and mitigating soft-errors affecting integrated circuit memory storage devices are provided. A soft-error mitigation process is invoked upon finding that an integrated circuit memory device is affected by a parity error. In a staged approach, unused memory regions of the integrated circuit memory device are reinitialized; if a redundant deployment prevails, the subsystem corresponding to the affected integrated circuit memory device is reset; memory regions having copies of contents thereof stored at remote locations are rewritten with obtained copies of the contents; and memory regions storing contents which are generated at run-time are reinitialized. Directed parity error scans are employed at each stage. If the parity error persists, one of the apparatus, and the subsystem corresponding to the affected silicon memory device is reset during a maintenance window. Advantages are derived from a run-time soft-error mitigation process which increases availability, and reduces maintenance overheads and the need for hardware replacement.