A recombinant polynucleotide encoding a Her2/neu target antigen is
provided, as is a recombinant Her2/neu target antigen polypeptide. Also
provided are methods of using such a recombinant polynucleotide to
express a Her2/neu target antigen in a cell. In addition, methods are
provided for using the recombinant polynucleotide or the recombinant
polypeptide to stimulate an immune response in a subject against cancer
that expresses Her2/neu. Methods of making a target antigen also are
provided.