The present invention provides a novel piperidine derivative and a
tachykinin receptor antagonist containing same, as well as a compound
represented by the formula:
wherein R.sup.1 is carbamoylmethyl, methylsulfonylethylcarbonyl and the
like; R.sup.2 is methyl or cyclopropyl; R.sup.3 is a hydrogen atom or
methyl; R.sup.4 is a chlorine atom or trifluoromethyl; R.sup.5 is a
chlorine atom or trifluoromethyl; and a group represented by the formula:
is a group represented by the formula:
wherein R.sup.6 is a hydrogen atom, methyl, ethyl or isopropyl; R.sup.7 is
a hydrogen atom, methyl or a chlorine atom; and R.sup.8 is a hydrogen
atom, a fluorine atom, a chlorine atom or methyl; or
3-methylthiophen-2-yl, and a salt thereof.