The present invention discloses compounds of Formula I: (I) having
11beta-HSD type 1 antagonist activity, as well as methods for preparing
such compounds. In another embodiment, the invention discloses
pharmaceutical compositions comprising compounds of Formula I, as well as
the use of the Fomula I and compositions as medicaments to treat
diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome
X, and other conditions associated with hyperglycemia.