A composition suitable for making a fiber or a film includes a biocompatible primary polymer matrix which forms a continuous phase of the composition and an active agent forming a substantially discontinuous phase of the composition. The biocompatible primary polymeric matrix has a glass transition temperature of less than about 100.degree. C. and is impermeable to the active agent. A process for making an article, such as a fiber or a film, includes the steps of providing a polymer blend comprising a polymer matrix having from 99.9 weight % to about 30 weight % of a biocompatible polymeric matrix and from about 0.1 to about 70 weight % of an active agent, wherein the weight % are based on the total weight of the of the polymeric matrix and active agent, and extruding the polymer blend into the article.