The present invention relates to novel members of the Tumor Necrosis
Factor family of receptors. The invention provides isolated nucleic acid
molecules encoding a human TR2 receptor and two splice variants thereof.
TR2 polypeptides are also provided as are vectors, host cells and
recombinant methods for producing the same. The invention further relates
to screening methods for identifying agonists and antagonists of TR2
receptor activity. Also provided are diagnostic methods for detecting
disease states related to the aberrant expression of TR2 receptors.
Further provided are therapeutic methods for treating disease states
related to aberrant proliferation and differentiation of cells which
express the TR2 receptors.