Medical devices and related methods for the treatment of spinal conditions are described herein. In one embodiment, a method includes disposing at least a portion of an implant in a space between adjacent spinous processes. The implant has a support member, a distal hub member, and an expandable member. At least a portion of the support member is disposed into the space between the adjacent spinous processes. A threaded member coupled to the distal hub member is rotated in a first rotational direction such that the distal hub member is moved in a first direction along a path defined by a longitudinal axis of the support member and at least a portion of the expandable member is moved to an expanded configuration.