Dry powder inhalers with a multi-dose dry powder package for dispensing
pharmaceutical grade formulations of inhalable dry powder, include: (a) a
blister package comprising a plurality of spaced apart sealed blisters
thereon, each blister having a projecting ceiling and a floor defining a
blister channel therebetween, the blister channel comprising a dry powder
therein; (b) a movable blade cartridge holding a blade at a forward
portion thereof; and (c) an extendable mouthpiece attached to the movable
blade cartridge. In operation, a user pulls the mouthpiece outward and
then pushes the mouthpiece inward to cause the blister package to advance
to position a blister in a selected dispensing position in the inhaler
and to cause the blade cartridge to move the blade across a blister
ceiling held in the dispensing position in the inhaler to thereby open
the blister held in the dispensing position.