The present invention is based on the discovery that a vascular stent or
other implantable medical device can be coated with a biodegradable
biocompatible polymer to which is attached a bioligand that specifically
captures progenitors of endothelial cells (PECs) from the circulating
blood to promote endogenous formation of healthy endothelium in Type II
diabetics. In one embodiment, the bioligand is a peptide that
specifically binds to an integrin receptor on PECs. The invention also
provides methods for using such vascular stents and other implantable
devices to promote vascular healing in Type II diabetics, for example
following mechanical intervention.