A composition and its use for local percutaneous delivery of a drug, in
particular a muscle relaxant, more particularly cyclobenzaprine present
in an amount of about 1 to about 10% by weight of the composition in an
organogel cream are disclosed. The composition is applied directly to the
skin over accessible muscles of mastication from which it is rapidly
absorbed through the skin to provide control of conditions such as
bruxism and tooth clenching. The composition can also be applied to the
skin overlying these muscles to control muscle hyperactivity (spasm)
and/or trigger points, from other causes. The composition can be
formulated to include another active agent such as a non-steroidal
anti-inflammatory, for example ketoprofen.