The present invention provides GPS receivers with clock calibration for fast reacquisition of GPS signals after waking up from a sleep state or coming out of signal blockage. In a preferred embodiment, a GPS receiver comprises a local clock based on an oscillator, e.g., crystal oscillator. The GPS receiver calculates a clock calibration value based on a computed oscillator count for the period during which the GPS receiver is in the sleep state or the signal is blocked. This clock calibration value is used to calibrate the local clock after the GPS receiver wakes up or comes out of signal blockage for fast reacquisition of GPS signals.