A system for personalized packaging of prescription medication includes a processing device having a CPU and a user interface. The user interface is configured to receive input data related to at least one type of medication to be packaged, wherein the user interface communicates the input data to the CPU for processing. A dispensing system is in communication with the processing device, wherein the dispensing system is configured to be pre-supplied with the at least one type of medication and to dispense the at least one type of medication based on the input data communicated from the CPU to the dispensing system. Also included in the system is a printing system in communication with the processing device. A printing system is configured to generate a print of instructional data based on the input data communicated from the CPU to the printing system, wherein the print of instructional data includes data correspondingly related to the at least one type of medication dispensed by the dispensing system. A packaging system is in communication with the dispensing system and configured to seal the at least one type of medication dispensed from the dispensing system within the personalized packaging.