A process for the preparation of optically active substituted
alpha-amino-indane derivatives of formula (I), which include: an
asymmetric hydrogenation reaction of an en-amide derivative of formula
(III) in presence of hydrogen and an optically active catalyst, in order
to obtain an amide derivative of formula (II), a hydrolysis reaction of
the amide derivative of formula (II) obtained in the previous step,in
order to obtain optically active substituted alpha-amino-indane
derivatives of formula (I).