The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: or a compound of Formula II: wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.8 are each independently hydrogen or C.sub.1-6 alkyl. R.sup.4 is absent or is hydrogen, C.sub.1-6 alkyl or C.sub.1-6 alkyl-OH. R.sup.5 is hydrogen, C.sub.1-6 alkyl or --NR.sup.6R.sup.7. R.sup.6 and R.sup.7 are each independently hydrogen or C.sub.1-6 alkyl, or are combined with the nitrogen to which they are attached to form a heterocycloalkyl having from 5 to 7 ring members. L is a linker of C.sub.1-6 alkylene, C.sub.2-6 alkenylene, C.sub.2-6 alkynylene or C.sub.3-6 cycloalkylene. The compounds of Formula I include the salts, hydrates and prodrugs thereof. Each R.sup.9 is H, C.sub.1-6 alkyl, --OH or --O--C.sub.1-6 alkyl. The compounds of Formulas I and II include the salts, hydrates and prodrugs thereof. By administering the compound of Formula I or II, the method inhibits the androgen receptor.