A content addressable memory device (100) and method can have CAM blocks (102-0 to 102-29) organized in block sections (104-0 to 104-6). In an overlay mode of operation, an overlay engine (106) can access an algorithmic search (SPEAR) CAM (102-28 and 102-29) to generate overlay data set search keys (keyFIB<0> and <1>). Multiple data sets (e.g., FIB0, FIB1, ACL0) can be accommodated on the same CAM device by search key multiplexers (108-0 to 108-6) that selectively apply any of a number of data set search keys (keyACL<0>, keyFIB<0> and keyFIB<1>).