A user interface design and evaluation system and a hand-interaction-based user interface design and evaluation system are provided. The user interface design and evaluation system includes: a user interface design unit, a human model interaction design unit, a user interface prototype simulation unit, a human model simulation unit, and a user interface evaluation unit. In order to develop a user interface in consideration of usability of a user, the system provides a usability evaluation feedback system performing optimization of an interface design based on a motion simulation of a body model and user interface model. Through this, an optimum interface design is derived and by reducing the initial usage difficulty of the new interface for a user, the user can easily use the new interface and work performance of the user can be enhanced. In addition, by supporting fast prototyping and evaluation in a new product development stage, efficient production of a product having a short life cycle can be actively implemented.