We identified a mechanism to detect chemical changes with a modified
semiconductor nanoparticle (e.g., an oxazine-adsorbed CdSe--ZnS
core-shell quantum dot). Our strategy is based on the chemical
transformation of chromo-genie ligands adsorbed on the surface of a
quantum dot. This activates an energy transfer pathway from the quantum
dot to the adsorbed chromogenic ligands, which causes a change (e.g.,
increase or decrease) in a characteristic of fluorescent emission (e.g.,
intensity or lifetime). Thus, modified quantum dots acting through this
mechanism can efficiently transduce a chemical event or occurrence into a
change in optical signal. Our design can be adapted to signal chemical
changes by a diversity of target analytes and, thus, it can be used to
develop other fluorescent chemosensors based on the unique properties of
quantum dots.