Amino acid diamides in non .alpha. position of formula (1), wherein R.sub.1 is selected from amongst the group consisting of the functional groups alkyl, halogen, NO.sub.2, OH, OCH.sub.3 alone or associated and R.sub.2 is selected from the group consisting of functional groups H, alkyl, halogen, NO.sub.2, OH, OCH.sub.3, which are useful as adjuvants for the administration of biological active agents, as well as pharmaceutical compositions containing these diamides of formula (1) and the use thereof for the manufacture of antithrombotic medications and for the manufacture of a medication for the treatment of a disease selected from amongst the group consisting of inflammation, cancer and allergy.