A method and a device are provided for regulating the charge pressure of an internal combustion engine having at least two exhaust gas turbochargers that set a target charge pressure rapidly and without overshooting. A first actuating element is provided with which the charge pressure of a first exhaust gas turbocharger is set, and a second actuating element is provided with which the charge pressure of a second exhaust gas turbocharger is set. Dependent on the exhaust gas back pressure prevailing in the exhaust gas channel at the output of the internal combustion engine, a first controlled variable is determined for the first actuating element, and a second controlled variable is determined for the second actuating element.