The present invention relates to the delivery of anti-migraine compounds
through an inhalation route. Specifically, it relates to aerosols
containing lidocaine, verapamil, diltiazem, isometheptene, or lisuride
that are used in inhalation therapy. In a method aspect of the present
invention, lidocaine, verapamil, diltiazem, isometheptene, or lisuride is
administered to a patient through an inhalation route. The method
comprises: a) heating a thin layer of lidocaine, verapamil, diltiazem,
isometheptene, or lisuride, on a solid support to form a vapor; and, b)
passing air through the heated vapor to produce aerosol particles having
less than 5% drug degradation products. In a kit aspect of the present
invention, a kit for delivering lidocaine, verapamil, diltiazem,
isometheptene, or lisuride through an inhalation route is provided which
comprises: a) a thin coating of a lidocaine, verapamil, diltiazem,
isometheptene, or lisuride composition and b) a device for dispensing
said thin coating as a condensation aerosol.