An injectable polymer-lipid blend is provided as a localized drug delivery
system for a pharmaceutically active agent. The blend may be prepared
from a chitosan-based material, fatty acid and phospholipid. The
chitosan-based material may be a water soluble chitosan derivative. The
fatty acid may be a fatty acid or a fatty aldehyde, such as
laurinaldehyde, having an acyl chain length of C8-C16. The rheological
properties of the blend relates to the ratio of the components and to the
acyl chain length of the fatty acid. The injectable system is well suited
for the delayed release of pharmaceutically active agents in the
treatment of cancer and other diseases requiring localized drug delivery.