Methods and apparatus to manage bypassing of a first cache are disclosed. In one such method, a load instruction having an expected latency greater than or equal to a predetermined threshold is identified. A request is then made to schedule the identified load instruction to have a predetermined latency. The software program is then scheduled. An actual latency associated with the load instruction in the scheduled software program is then compared to the predetermined latency. If the actual latency is greater than or equal to the predetermined latency, the load instruction is marked to bypass the first cache.