Secure methods of distributing and prescribing prescription medications and related systems significantly increase prescription medication distribution security. Applications of the present invention are particularly useful in prescribing and distributing lifestyle drugs where an actual physical examination is not necessarily required, but are similarly useful for all prescription medications. A system configured according to a particular embodiment of the present invention involves a prescription request kiosk, a prescription request review terminal, a medical information database, and a pharmacy all associated with a prescription distribution system processor. Particular embodiments of prescriptions of the present invention include a photograph of a prescription requestor on the prescription for added security along with additional follow-up questions to be asked by the pharmacist to the customer. Requestors initiate prescription requests by answering a plurality of questions related specifically to the prescription medications requested.