The present invention provides compound of the formula (I): ##STR00001## in which at least two of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are N.sub.2O.sub.2M and related compounds substrates, compositions, and methods of using such compounds and compositions to treat biological disorders in which a polyphasic release of nitric oxide would be beneficial.