A compound of the formulae (I) or (II): ##STR00001## wherein: Y is a
moiety selected from NR or --(CH.sub.2).sub.n; wherein R is hydrogen or
(C.sub.1-C.sub.6) lower alkyl, and n is 1; ##STR00002## represents:
(1) a phenyl ring optionally substituted with one or two substituents
selected, independently, from the group comprising hydrogen,
(C.sub.1-C.sub.6) lower alkyl, halogen, cyano, CF.sub.3, hydroxy,
(C.sub.1-C.sub.6) lower alkoxy, (C.sub.1-C.sub.6) lower alkoxy carbonyl,
carboxy, --CONH.sub.2, --CONH[(C.sub.1-C.sub.6) lower alkyl],
--CON[(C.sub.1-C.sub.6) lower alkyl].sub.2; or(2) a 6-membered aromatic
(unsaturated) heterocyclic ring having one nitrogen atom, optionally
substituted by (C.sub.1-C.sub.6) lower alkyl, halogen or
(C.sub.1-C.sub.6) lower alkoxy; ##STR00003## represents:(1) a phenyl
ring optionally substituted with one or two substituents selected,
independently, from the group comprising hydrogen, (C.sub.1-C.sub.6)
lower alkyl, halogen, cyano, CF.sub.3, hydroxy, (C.sub.1-C.sub.6) lower
alkoxy, or (C.sub.1-C.sub.6) lower alkoxy carbonyl, carboxy,
--CONH.sub.2, --CONH[(C.sub.1-C.sub.6) lower alkyl],
--CON[(C.sub.1-C.sub.6) lower alkyl].sub.2; or(2) a 5-membered aromatic
(unsaturated) heterocyclic ring having one nitrogen atom, optionally
substituted by (C.sub.1-C.sub.6) lower alkyl, (C.sub.1-C.sub.6) lower
alkoxy, or halogen; or(3) a 6-membered aromatic (unsaturated)
heterocyclic ring having one nitrogen atom, optionally substituted by
(C.sub.1-C.sub.6) lower alkyl, halogen, or (C.sub.1-C.sub.6) lower
alkoxy; ##STR00004## represents a 5-membered aromatic (unsaturated)
heterocyclic ring having one sulfur atom, optionally substituted by
(C.sub.1-C.sub.6) lower alkyl, halogen, or (C.sub.1-C.sub.6) lower
alkoxy;R.sub.1 is a moiety of the formula ##STR00005## and R.sub.2,
R.sub.3, R.sub.7, R.sub.8 and R.sub.9 are, independently, selected from a
group consisting of hydrogen, (C.sub.1-C.sub.3) lower alkyl, OCH.sub.3,
halogen, CF.sub.3, --SCH.sub.3, OCF.sub.3, SCF.sub.3, or CN; or a
pharmaceutically acceptable salt, or pro-drug form thereof.
