A method for detecting and removing small isolated fragments in a 3D segmented volume is disclosed. The 3D segmented volume is projected onto several 2D images from different viewing directions. Isolated 2D fragments are detected in the 2D images. Corresponding 3D fragments are found in the 3D volume by unprojecting corresponding detected 2D fragment locations. The unprojected detected 2D fragment locations are used as seed points for region growing of isolated 3D fragments. Any of the 3D fragments having a volume size below a user-defined threshold are discarded.