Compounds of formula I ##STR00001## in free or salt form, wherein R.sup.1, R.sup.2 and R.sup.3 have the meanings as indicated in the specification, are useful for treating conditions mediated by of phosphodiesterase type 4 or the down-regulation or inhibition of TNF-.alpha. release, particularly obstructive or inflammatory airways diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

 
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< Protein based TNF-.alpha. variants for the treatment of TNF-.alpha. related disorders

> Methods of determining the level of human TBP-II with anti-TBP-II antibody

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