A treatment brassiere includes a breasts-supporting garment and a treatment layer. The breast-supporting garment includes at least a breast support having an inner surface and a securing device for securing the breast support on a user that the inner surface of the breast support is contacting with the breast surface of the user. The treatment layer, which is made of a non-absorptive material with respect to a breast treatment, is fittingly provided on the inner surface of the breast support, wherein the treatment layer form as a treatment barrier between the breast surface of the user and the inner surface of the breasts-supporting garment for substantially keeping the breast treatment on the breast surface.