A medical device comprising a substrate having a plasma polymerized
functionality bonded to at least a portion of the substrate. A superoxide
dismutase mimic agent having a complimentary functional group to the
plasma polymerized functionality is bonded to the portion of the
substrate by bonding to the plasma polymerized functionality. The
functionalities can be carboxylate, amine, or sulfate groups and/or
polyethylene glycol and can optionally include crosslinking groups.