A diagnosis, therapy and prognosis system (DTPS) and method thereof to help either the healthcare provider or the patient in diagnosing, treating and interpreting data are disclosed. The apparatus provides data collection based on protocols, and mechanism for testing data integrity and accuracy. The data is then driven through an analysis engine to characterize in a quantitative sense the metabolic state of the patient's body. The characterization is then used in diagnosing the patient, determining therapy, evaluating algorithm strategies and offering prognosis of potential use case scenarios.