An optical measurement device for measurement of chemical and/or biological samples comprises an illumination means (16) for illuminating the sample (20) to be measured. Further, an optics means (22) is provided for imaging a sample area in an image field (10). A first partial area (12) of the image field is covered by a first detector (28), and a second partial area (14) of the image field (10) is covered by a second detector (34). Thus, it is possible to change between two measurement methods without switching or to perform two measurements on a sample at the same time.